Alendronate: What It Is and How It Helps Your Bones

If you’ve been told you have osteoporosis or low bone density, chances are your doctor mentioned alendronate. It’s a pill that belongs to the bisphosphonate family and works by slowing down the cells that break down bone. The result is stronger bones and a lower risk of fractures.

Alendronate is usually taken once a week. The most common brand in the U.S. is Fosamax, but there are generic versions that work the same way. You’ll get a prescription that tells you the exact dose—most people start with 70 mg per week.

How to Take Alendronate the Right Way

The trick isn’t the medication itself; it’s the way you take it. First, take the tablet with a full glass of plain water—no juice, coffee, or soda. This helps the pill move down your throat quickly and reduces irritation.

After swallowing, stay upright for at least 30 minutes. Sitting or lying down can let the tablet linger in your esophagus, which may cause burning or ulcers. Also, avoid eating, drinking anything other than water, or taking other meds for that half‑hour window.

If you miss a dose, just take the next scheduled tablet and skip the missed one. Don’t double up to catch up.

Common Side Effects and When to Call Your Doctor

Most people tolerate alendronate well, but a few side effects pop up. The most frequent are mild stomach upset, heartburn, or a strange taste. Some folks notice flu‑like symptoms after the first few doses—fever, muscle aches, or chills. Those usually fade after a week.

Watch for more serious signs like severe chest pain, trouble swallowing, or persistent sore throat. If any of these happen, stop the medication and call your doctor right away.

To keep your stomach happy, consider taking a calcium supplement at a different time of day—at least two hours after the alendronate dose. Antacids, vitamin C, or iron should also be spaced out.

Tips for Getting the Most Out of Alendronate

1. Keep a reminder on your phone for the weekly dose. Consistency matters. 2. Store the bottle upright in a cool, dry place. Moisture can affect the tablet. 3. Bring a water bottle to the pharmacy when you pick up a refill. You’ll always have a full glass ready. 4. Ask your doctor about a bone density test after a year of treatment. It shows whether the drug is working. 5. If you have trouble swallowing the tablet, ask about a liquid version or a different bisphosphonate.

Alendronate isn’t a cure for osteoporosis, but it’s a proven tool to slow bone loss and cut fracture risk. Pair it with weight‑bearing exercise, a balanced diet, and regular doctor visits for the best results.

Below you’ll find other health articles on our site that might interest you, from supplement guides to alternative medications. Browse the list to learn more about staying healthy and making smart medication choices.

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Medication Guides
Drug Holidays for Alendronate: When to Pause Based on T-Score and Fracture Risk

Not sure if or when to take a break from your alendronate (Fosamax) medication? Get a plain-English breakdown on when to consider a 'drug holiday,' using clear benchmarks like your T-score and fracture history. This guide sorts through the science, shares real-life decision points, and answers the most common questions about pausing osteoporosis treatment—and how it could affect your bone health. Perfect for anyone who wants practical tips on managing long-term bone medication. Keep your bones strong while minimizing unnecessary risks.