Zidovudine (AZT) – What You Need to Know

If you or someone you know is living with HIV, you’ve probably heard the name zidovudine, often called AZT. It’s one of the oldest antiretroviral drugs and still shows up in treatment plans today. This page breaks down the basics – from how it fights the virus to what to expect when you start taking it.

How Zidovudine Works

Zidovudine belongs to a class called nucleoside reverse transcriptase inhibitors (NRTIs). In plain terms, it tricks the virus into thinking it’s a building block of DNA. When HIV tries to copy its genetic material, zidovudine slips in and stops the process, slowing the virus down. Slower virus replication means the immune system gets a chance to recover and stay stronger.

The drug is usually combined with other antiretrovirals. This combo approach, called HAART (highly active antiretroviral therapy), reduces the chance of the virus becoming resistant. Most doctors prescribe zidovudine alongside newer drugs for a balanced regimen.

Practical Tips: Dosage, Safety & Where to Get It

Typical dose: Adults start with 300 mg taken twice daily, but doctors may adjust the amount based on weight, kidney function, and any other meds you’re on. Kids get a weight‑based dose, so follow the pediatric schedule carefully.

Taking it right: Swallow the tablet with a full glass of water. You can take it with food to avoid stomach upset, but keep the timing consistent – same times each day helps maintain steady drug levels.

Common side effects include mild nausea, headache, and fatigue. Some people notice a temporary drop in blood counts (anemia or neutropenia). If you feel dizzy, short of breath, or notice unusual bruising, contact your doctor fast – they may need to check your blood work.

Drug interactions matter. Zidovudine can interact with certain antibiotics (like trimethoprim‑sulfamethoxazole), some antifungals, and other antiretrovirals. Always share your full medication list with your healthcare provider.

Buying safely: Because zidovudine is prescription‑only, avoid black‑market sites. Look for licensed online pharmacies that require a valid prescription, display a physical address, and have a pharmacist contact. Check reviews, make sure the site uses secure (HTTPS) connections, and compare prices with local pharmacies to spot deals.

When you receive the medication, inspect the packaging. The pills should match the description on your prescription label and be free of any damage. Store them at room temperature, away from moisture and heat.

Finally, never stop zidovudine without talking to your doctor. Stopping abruptly can let the virus rebound quickly, making the disease harder to control.

In short, zidovudine is a reliable component of many HIV treatment plans when used correctly. Understanding how it works, following the prescribed dosage, watching for side effects, and buying from reputable sources will help you stay on track with your health goals.